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Pyometra in Cats

In its simplest terms, pyometra is an infection in the uterus. However, most cases of pyometra are much more difficult to manage than a routine infection.

Prevalence

This disease does not occur in cats that have been spayed (unless part of the uterus was not removed). It may occur in young to middle-aged cats; however, it is most common in cats older than five years of age. After many years of estrous cycles without pregnancy, the uterine wall undergoes the changes that promote this disease.

The typical time for pyometra to occur is about 1-2 months following estrus.

Clinical Signs

Clinical signs depend on whether or not the cervix is open. If it is open, pus will drain from the uterus through the vagina to the outside. It may be noted on the skin or hair under the tail or on bedding and furniture where the cat has laid; however, the fastidious nature of the cat usually causes her to clean up the discharge before it can be seen. This usually prohibits owners from seeing the discharge. Fever, lethargy, anorexia, and depression may or may not be present.

If the cervix is closed, pus that forms is not able to drain to the outside. It collects in the uterus causing distention of the abdomen. The bacteria release toxins that are absorbed into circulation. These cats often become severely ill very rapidly. They are anorectic, very listless, and very depressed. Vomiting or diarrhea may be present.

Toxins released by the uterine bacteria affect the kidney's ability to retain fluid. Increased urine production occurs, and the cat drinks an increased amount of water. This occurs in both open- and closed-cervix pyometra.

Causes

Infection in the lining of the uterus is established as a result of hormonal changes. Following estrus ("heat"), progesterone levels remain elevated for 8-10 weeks and thicken the lining of the uterus in preparation for pregnancy. If pregnancy does not occur for several estrous cycles, the lining continues to increase in thickness until cysts form within it. The thickened, cystic lining secretes fluids that create an ideal environment in which bacteria can grow. Additionally, high progesterone levels inhibit the ability of the muscles in the wall of the uterus to contract.

Other Causes

The use of progesterone-based drugs can cause pyometra. In addition, estrogen will increase the effects of progesterone on the uterus. Drugs containing both hormones are used to treat certain conditions of the reproductive system.

Entry of Bacteria into the Reproductive Tract

The cervix is the gateway to the uterus. It remains tightly closed except during estrus. When it is open, bacteria that are normally found in the vagina can enter the uterus rather easily. If the uterus is normal, the environment is not well suited to bacterial survival; however, when the uterine wall is thickened and cystic, perfect conditions exist for bacterial growth. In addition, when these abnormal conditions exist, the muscles of the uterus cannot contract properly. This means that bacteria that enter the uterus cannot be expelled.

Diagnosis

Cats that are seen early in the disease may have a slight vaginal discharge and show no other signs of illness. However, most cats with pyometra are not seen until later in the illness. Any very ill female cat that is drinking an increased amount of water and has not been spayed is always suspected of having pyometra. This is especially true if there is a vaginal discharge or an enlarged abdomen.

Cats with advanced pyometra have a marked elevation of the white blood cell count and often have an elevation of globulins (a type of protein produced by the immune system) in the blood. The urine may be very dilute due to the toxic effects of the bacteria on the kidneys. However, all of these abnormalities may be present in any cat with a major bacterial infection.

If the cervix is closed, radiographs (x-rays) of the abdomen will often identify the enlarged uterus. If the cervix is open, there will often be such minimal uterine enlargement that the radiograph will not be conclusive. An ultrasound examination can also be helpful in identifying an enlarged uterus and differentiating that from a normal pregnancy.

Treatment

The preferred treatment is to surgically remove the uterus and ovaries. This is called an ovariohysterectomy ("spay"). Cats diagnosed in the early stage of the disease are very good surgical candidates. The surgery is more complicated than a routine spay because a very large, pus-filled uterus must be removed with rupturing it. Recovery is also more complicated. Intravenous fluids are often needed before and after surgery; antibiotics are given for 1-2 weeks.

Non-surgical Therapy

There is a medical approach to treating pyometra. Prostaglandins are a group of hormones that reduce the blood level of progesterone, relax and open the cervix, and contract the uterus to expel bacteria and pus. They can be used to treat this disease, but they are not always successful, and they have some important limitations.

  1. They cause side effects of restlessness, panting, vomiting, defecation, salivation, and abdominal pain. The side effects occur within about 15 minutes of an injection and last for a few hours. They become progressively milder with each successive treatment.
  2. There is no clinical improvement for about 48 hours so cats that are severely ill are poor candidates.
  3. Because they contract the uterus, it is possible for the uterus to rupture and spill infection into the abdominal cavity. This is most likely to happen when the cervix is closed.

There are some important statistics that you should know about this form of treatment:

  1. The success rate for treating open-cervix pyometra is 75-90%.
  2. The success rate for treating closed-cervix pyometra is 25-40%.
  3. The rate of recurrence of the disease is 50-75%.
  4. The chances of subsequent successful breeding are 50-75%.

Prognosis

Cats that have surgery are expected to recovery completely unless they are not treated until the infection has spread widely throughout the body (septicemia). Cats treated with prostaglandin therapy generally recover; however, if that form of treatment is not successful, surgery is still an option.

The chance of successful treatment without surgery or prostaglandin treatment (ie., only with antibiotics) is extremely low. If treatment is not performed quickly, the toxic effects from the bacteria will be fatal. If the cervix is closed, it is also possible for the uterus to rupture, spilling the infection into the abdominal cavity. This will also be fatal.